For the first time in nine years, the U.S. Open returns to Oakmont Country Club. Bryson DeChambeau, last year’s U.S. Open winner, will try to become the first back-to-back winner of the event since Brooks Koepka accomplished the feat in 2017 and 2018. This will be the third time that Oakmont will play host to the event, and the U.S. Open 2025 begins on Thursday with Round 1. Scottie Scheffler enters as the +280 favorite (risk $100 to win $280) in the 2025 U.S. Open odds, followed by DeChambeau (+700), Rory McIlroy (+1100) and Jon Rahm (+1200). Koepka is a +5000 (50-1) long shot. Who should you consider when you place your 2025 U.S. Open betting picks? Before locking in your 2025 U.S. Open picks, be sure to see the golf predictions and projected leaderboard from the proven computer model at SportsLine.

SportsLine’s proprietary model, built by DFS pro Mike McClure, has been red-hot since the PGA Tour resumed in June 2020. In fact, the model is up nearly $9,000 on its best bets since the restart, nailing tournament after tournament.

This same model has also nailed a whopping 15 majors entering the weekend, including the 2025 Masters – its fourth Masters in a row – and the 2025 PGA Championship. Anyone who has followed its sports betting picks could have seen massive returns on betting sites and for anyone taking advantage of the latest FanDuel promo code, DraftKings promo code and Fanatics Sportsbook promo code.

Now that the 2025 U.S. Open field is taking shape, SportsLine simulated the tournament 10,000 times, and the results were surprising. Head to SportsLine now to see the projected leaderboard.

2025 U.S. Open predictions

One major surprise the model is calling for at the 2025 U.S. Open: Rory McIlroy, a past U.S. Open champion and the third-favorite at +1100, stumbles and falls all the way out of the top five. Since winning the 2025 Masters, which completed his career grand slam, he has struggled of late. He missed the cut at the Zurich Classic on April 23.

At the Truist Championship on May 7, he finished tied for seventh. He followed that up with a 47th-place at the PGA Championship. Last week at the RBC Canadian Open, he missed the cut after posting a 71 and 78 for a nine-over-par 149. Despite all of his past successes, the model sees better value elsewhere. See who else to fade here.

Another surprise: Justin Thomas, a 40-1 longshot, makes a strong run at the title. He has a much better chance to win it all than his odds imply, so he’s a target for anyone looking for a huge payday. Thomas has been playing well in 2025, securing one win and six top-10 finishes across 13 starts. He finished on top of the leaderboard at the RBC Heritage, his first victory since the 2022 PGA Championship.

Thomas has been able to secure those positive results thanks in large part to his consistent putting stroke. The two-time major champion enters Oakmont ranked first in putting average (1.658), third in putts per round (27.72) and sixth in one-putt percentage (45.00%). Breaking par at a tough course like Oakmont will be a challenge for many golfers, but Thomas’ game seems well-suited for success at the U.S. Open. See who else to pick here.

How to make 2025 U.S. Open picks

The model is also targeting four other golfers with odds of 25-1 or longer who will make a strong run at the title. Anyone who backs these longshots could hit it big. You can only see the model’s picks here.

Who will win the 2025 U.S. Open, and which longshots will stun the golfing world? Check out the 2025 U.S. Open odds below and then visit SportsLine to see the projected leaderboard, all from the model that’s nailed 15 golf majors, including the last four Masters and the first two majors in 2025.

2025 U.S. Open odds, favorites

Get full 2025 U.S. Open picks, best bets, and predictions here.

(odds subject to change)

Scottie Scheffler +280

Bryson DeChambeau +700

Rory McIlroy +1100

Jon Rahm +1200

Xander Schauffele +2200

Collin Morikawa +2500

Ludvig Åberg +3000

Joaquin Niemann +3300

Tommy Fleetwood +4000

Justin Thomas +4000

Shane Lowry +4000

Patrick Cantlay +4500

Tyrrell Hatton +5000

Brooks Koepka +5000

Sepp Straka +5000

Jordan Spieth+5500

Viktor Hovland +5500

Hideki Matsuyama +6500

Corey Conners +7000

Ben Griffin +7000

Russell Henley +7000

Sam Burns +8000

Justin Rose +10000

Patrick Reed +10000

Keegan Bradley +10000

Matt Fitzpatrick +10000

Harris English +10000

Maverick McNealy +11000

Daniel Berger +11000

Tony Finau +11000

Si Woo Kim +11000

Robert MacIntyre +11000

Taylor Pendrith +12000

Aaron Rai +12000

Sungjae Im +12000

Jason Day +12000

Ryan Fox +12000

Cameron Young +15000

Wyndham Clark +15000

Cameron Smith +15000

Akshay Bhatia +15000

Min Woo Lee +15000

J.J. Spaun +15000

Thorbjørn Olesen +17000

Denny McCarthy +17000

Brian Harman +17000

Nick Taylor +17000

Andrew Novak +17000

Adam Scott +17000

J.T. Poston +17000

Dustin Johnson +17000

Ryan Gerard +22000

Gary Woodland +22000

Lucas Glover +22000

Michael Kim +22000

Carlos Ortiz +22000

Davis Thompson +22000

Marc Leishman +22000

Tom Kim +22000

Bud Cauley +25000

Max Greyserman +25000

Byeong Hun An +25000

Thomas Detry +25000

Eric Cole +25000

Rasmus Neergaard-Petersen +27000

Johnny Keefer +30000

Stephan Jaeger +30000

Tom Hoge +30000

Sam Stevens +30000

Rasmus Højgaard +30000

Jordan Smith +30000

Jackson Koivun +30000

Phil Mickelson +30000

Mackenzie Hughes +30000

Matt Wallace +30000

Davis Riley +35000

Christiaan Bezuidenhout +35000

Jhonattan Vegas +35000

Erik van Rooyen +35000

Niklas Norgaard +35000

Doug Ghim +35000

Nico Echavarria +40000

Matt McCarty +40000

Matthieu Pavon +40000

Jacob Bridgeman +40000

Cam Davis +40000

Chris Kirk +40000

Richard Bland +40000

Emiliano Grillo +40000

Victor Perez +40000

Laurie Canter +50000

Chris Gotterup +50000

Mark Hubbard +50000

Takumi Kanaya +50000

Ben James +60000

Michael La Sasso +60000

Justin Lower +60000

Jinichiro Kozuma +75000

Joe Highsmith +75000

Sam Bairstow +75000

Matthew Jordan +75000

Edoardo Molinari +75000

Emilio Gonzalez +100000

Evan Beck +100000

Alistair Docherty +100000

Joakim Lagergren +100000

Alvaro Ortiz +100000

Ryan McCormick +100000

Tyler Weaver +100000

Riley Lewis +100000

Joey Herrera +100000

Frederic LaCroix +100000

Andrea Pavan +100000

Mason Howell +100000

Matt Vogt +100000

James Hahn +100000

Adam Schenk +100000

Jacques Kruyswijk +100000

Kevin Velo +100000

Trevor Cone+100000

James Nicholas +100000

Grant Haefner +100000

Brady Calkins +100000

Noah Kent +100000

Yuta Sugiura +100000

Lanto Griffin +100000

Justin Hicks +100000

Will Chandler +100000

Trevor Gutschewski +100000

Brian Campbell +100000

Scott Vincent +100000

Thriston Lawrence +100000

Chandler Blanchet +100000

George Kneiser +100000

Trent Phillips +100000

Zachery Pollo +100000

Frankie Harris +100000

Bryan Lee +100000

Jackson Buchanan +100000

Philip Barbaree +100000

Cameron Tankersley +100000

Justin Hastings +100000

Guido Migliozzi +100000

Nick Dunlap +100000

Preston Summerhays +100000

George Duangmanee +100000

Zac Blair +100000

Jose Luis Ballester Barrio +100000

Roberto Díaz +100000

Austen Truslow +100000

Harrison Ott +100000

Zach Bauchou +100000

Lance Simpson +100000

Maxwell Moldovan +100000

Chase Johnson +100000

Riki Kawamoto +100000