The Week 1 NFL schedule has arrived, It’s another strong opening slate that begins with Cowboys vs. Eagles in the 2025 NFL Kickoff Game tonight, followed by Chiefs vs. Chargers in Brazil on Friday. Thirteen games are on the Sunday schedule, with Vikings vs. Bears wrapping it up on Monday. NFL bettors are often targeting spreads, totals and money-line NFL picks. Some key Week 1 NFL odds include the Eagles at -8.5 against the Cowboys and the Packers at -2.5 versus the Lions. The Bills, meanwhile, are +1.5 against the Ravens in a Sunday Night Football showdown between AFC contenders. The week concludes with the Vikings (-1.5) visiting the Bears on Monday Night Football.

A set of exact Week 1 NFL score predictions can give you the tools needed to make a variety of picks for every game, as well as a guide for some NFL props you could target as well. Hitting on an exact NFL score prediction could also result in a huge payday. Before making any Week 1 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

A SportsLine expert and host, Cohen is evaluating the entire Week 1 NFL slate and delivers score predictions and logic for each matchup. He finished the 2024-25 season with a 190-95 record on straight up NFL betting picks (69%) and was profitable for bettors. Anyone who followed Cohen’s NFL predictions has been profitable at their favorite sports betting sites and betting apps.

You can only see Cohen’s Week 1 NFL exact score predictions at SportsLine. Also, new users can take advantage of the DraftKings promo code, which offers $300 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

Top Week 1 NFL picks

After diving into all 16 games from the NFL’s Week 1, Cohen likes the Bills (+1.5, 50.5) to narrowly win a rematch of their AFC Divisional Playoff Game victory over the Ravens in a 26-23 final. “In my opinion, these are the two best teams in the NFL and we’ll see this matchup again on Sunday, January 25th, 2026 in the AFC Championship Game.”

“I have Buffalo going 15-2 this season but Baltimore winning the Super Bowl. If I had to do a home field advantage ranking, the passionate Bills crowd would easily be in the top-5, if not No. 1 overall. That’s the difference in a game that should be very similar to last year’s playoff contest narrowly won by Buffalo.” With that score prediction, Cohen likes the Bills on the money line (-104), to cover the small spread and the Over to hit in this matchup, even though it is the highest total on the Week 1 NFL odds board. See his other Week 1 football score predictions at SportsLine.

How to make Week 1 NFL score predictions

In addition, Cohen is calling for one game to exceed 60 total points this week, making the Over a must bet. Nailing this result is key to making profitable Week 1 NFL picks. You can only see it at SportsLine.

Who wins every Week 1 NFL game, and which games is a must bet for the over? Visit SportsLine now to get Eric Cohen’s NFL Week 1 score predictions, all from the NFL expert who nailed nearly 70% of his NFL straight-up picks last season, and find out.