It’s the #endofanera, according to longtime E! News host Giuliana Rancic.

The former E! News host spoke out in a heartfelt Instagram post after the entertainment news program’s cancellation was announced July 24, telling fans that “for 20 incredible years, E! News was my second home and family.”

Rancic starred on E! News from 2005 to 2021, joining as a cohost in 2006, including some hiatuses. Rancic, arguably one of the show’s biggest stars alongside former on-air anchor Ryan Seacrest, left the show after the program’s indefinite hiatus in March 2020 due, in part, to the network’s suspension of all in-studio work amid the COVID-19 pandemic.

The program will continue to air new episodes through Sept. 25. and E! plans to maintain its digital presence with its E! Online website. Staffers were informed of the cancellation on Thursday, July 24, and new episodes are expected to return next week.

E! News to go off the air in fall 2025 in second cancellation

Need a break? Play the USA TODAY Daily Crossword Puzzle.

“As the show comes to an end, I feel so fortunate to have been a part of this pop culture phenomenon that aired in over 100 countries and allowed me to travel around the globe meeting the most amazing and loyal viewers,” Rancic wrote on Instagram.

“Thank you to every single one of you for letting us into your homes every night,” Rancic continued. “Anchoring E! News was my dream job and the professional honor of a lifetime #endofanera.”

The show returned in November 2022 after it was revived as a late-night news program, co-anchored by actress-singer Adrienne Bailon-Houghton and host Justin Sylvester, who found fame first on the “Real Housewives of Beverly Hills.” After Bailon-Houghton departed, ex-“Entertainment Tonight” correspondent Keltie Knight joined Sylvester as cohost.

“E! News,” known for its punchy insider look at the entertainment industry, was originally hosted by reporter Dagny Hultgreen. Over the years, the newscast has featured on-air talent including Rancic, Seacrest, Jason Kennedy, Zuri Hall, Terrence Jenkins (better known as Terrence J), Maria Menounos and Catt Sadler.

Some “E! News” correspondents will transition over to Versant, a spin-off of parent company NBCUniversal, although specific job opportunities have not been finalized.

E! will continue to air its non-news programming, which includes reality-TV shows such as “Botched Presents: Plastic Surgery Rewind” and “Honestly Cavallari: The Headline Tour,” as well as upcoming series “Kimora: Back in the Fab Lane” and “E!’s Dirty Rotten Scandals.”