During his six-week trial, Harvey Weinstein often nodded off during testimony. He looked pale and frail as he was wheeled into the Manhattan criminal courthouse, arriving from his secured unit at Bellevue Hospital Center.

Mr. Weinstein, once an imposing force in Hollywood, has been in poor health in recent years, according to his lawyers, who have listed diabetes, spinal stenosis and fluid on his heart and lungs among his many ailments. Last September, he was hospitalized for emergency heart surgery. The next month, he was diagnosed with cancer.

Mr. Weinstein’s condition played a role during jury selection in his first trial in 2020, when he used a walker to shuffle into the courtroom following back surgery. By then, he was no longer the robust movie executive sitting proudly at the front of awards ceremonies. Instead, potential jurors saw a diminished, considerably thinner man at the defense table, and prosecutors wanted to make sure they could look past his physical appearance.

Five years later, his health appears to be much worse, but this time prosecutors did not probe jurors’ feelings about it during jury selection. During their closing arguments, however, prosecutors tried to remind the jury that during deliberations they should remember Mr. Weinstein at the peak of his powers, when he was still a Hollywood mogul, wearing sharp suits and laughing with movie stars.