The Israel-Iran conflict entered its fifth day Tuesday with continued airstrikes and soaring casualties — 452 dead and 646 injured in Iran, and 24 killed in Israel. Israel claimed the killing of another top Iranian general.

Trump escalated tensions by threatening its supreme leader Ayatollah Ali Khamenei, stating he would not be killed “for now” and demanding Tehran’s “unconditional surrender.” Trump’s latest comments suggest the U.S. might reconsider its stance amid rising regional conflict.

Trump had earlier warned Iran against pursuing nuclear weapons and said he’s “not in the mood to negotiate.”

Tehran witnessed fresh explosions near state TV offices; daily life is paralyzed as sirens wail, residents flee, and fuel queues grow. Internet and international calls were disrupted, and a cyberattack hit Iran’s oldest bank, Bank Sepah, with hacker group “Predatory Sparrow” claiming responsibility.

Iran’s new military chief Abdolrahim Mousavi says Tehran has only launched attacks to deter Israel, and “punitive operation will be executed soon”.

Russia and India are evacuating its citizens from Iran, Moscow has said Israel has shown no interest in mediation. A UN summit on the Israel-Palestine issue, co-hosted by France and Saudi Arabia, has been postponed indefinitely due to security concerns.

Maj. Gen. Ali Shadmani, a senior Iranian commander, has been killed in an Israeli airstrike, days after taking over a top military post amid escalating strikes targeting Iran’s leadership. The Israel Defense Forces (IDF) said Shadmani was killed Monday during a precision airstrike on central Tehran. Shadmani had been appointed head of Iran’s Khatam-al Anbiya Central Headquarters—Iran’s military emergency command—following the death of his predecessor, Maj. Gen. Gholam Ali Rashid, in the opening round of Israeli strikes on Tehran last Friday.

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Those initial strikes, which Israeli officials described as a direct response to Iranian aggression and expanding nuclear capabilities, targeted multiple sites across the capital, including the headquarters of the Islamic Revolutionary Guards Corps (IRGC).

The IDF confirmed the deaths of three senior Iranian military leaders in its opening campaign: the Chief of Staff of the Iranian Armed Forces, the Commander of the IRGC, and the head of Iran’s emergency military command. “These are three ruthless mass murderers with international blood on their hands,” an IDF said in a statement. “The world is a better place without them.”

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The IDF also reported the elimination of a senior commander from the IRGC’s Air Force and claimed that multiple nuclear scientists involved in weapons development had been killed. Below is a summary of the key figures reported killed so far: Military personnel and aides General Gholam Ali Rashid Rashid was confirmed dead after the airstrikes in Tehran, alongside his son. He was deputy commander in chief of the armed forces, and commander of Khatam-al Anbiya Central Headquarters, a branch of the IRGC. Rashid was key in the operations of Iran’s unmanned aerial vehicle (UAV) programme, mostly consisting of the use of drones in warfare. In February, the general vowed to retaliate against any strikes on Iran’s nuclear program after reports of plans from Israel and the U.S. to strike nuclear targets in Iran by “mid-2025.” Major General Hossein Salami Gen. Hossein Salami, commander-in-chief of the Islamic Revolutionary Guards Corps, Iran’s main military force, was a key figure in the political sphere. It’s understood he reported directly to Ayatollah Ali Khamenei.

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Salami rose to power around six years ago, and during his time as Major General of the IRGC, he repeatedly threatened Israel and the U.S. with military action. After the 2020 death of Qasem Soleimani, the head of IRGC Qud’s Force, who was killed in a U.S. airstrike on a base in Baghdad, Salami said: “If they [Israel and the U.S.] threaten our commanders, none of their commanders will find a safe place” to live. Days after the death of Soleimani, Iran launched a number of missiles at American military facilities in Iraq, with no casualties reported. Khamenei has announced that Salami will be replaced by Brigadier General Mohammad Pakpour. Read more: How Involved Was the U.S. in Israel’s Attack on Iran? Major General Mohammad Bagheri Mohammad Bagheri served as the Chief of Staff to Iran’s armed forces, a position he acquired in 2016 which saw him oversee an estimated 610,000 personnel. He was the second-highest commander after Supreme Leader Ayatollah Ali Khamenei.

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Born in 1960, Bagheri was head of “the most senior military body in Iran, which implements policy and monitors and coordinates activities within the armed forces,” according to U.S. Treasury documents detailing sanctions against the general in 2019. Bagheri will be replaced by Major General Abdolrahim Mousavi, as announced by Ayatollah Khamenei. Commander Amir Ali Hajizadeh Ali Hajizadeh was the commander of the IRGC. Upon announcing his death, the IDF said Hajizadeh “had assembled in an underground command center to prepare for an attack on the State of Israel.” The IRGC described the general as “a prominent and influential figure of the resistance front and a symbol of development, innovation, and might in the defense and missile spheres.” Gen. Gholamreza Mehrabi Gen. Gholamreza Mehrabi served as the deputy intelligence chief of the Iranian Armed Forces. Gen. Mehdi Rabbani Gen. Mehdi Rabbani was a top-ranking official and served as the deputy commander of operations for the Iranian Armed Forces.

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Ali Shamkhani Ali Shamkhani, a close aide to Ayatollah Khamenei, was reportedly killed in Israel’s first attack on Iran last week, according to state media. However, it has since been reported that he is injured and currently in ICU, according to a news site associated with Shamkhani. The report stated that Shamkhani was injured in the strikes, and his since been brought under a stable condition whilst doctors continue to monitor his injuries, most of which were internal. Shamkhani was part of the Iranian delegation which secured the restoration of diplomatic ties with Saudi Arabia in March 2023. Despite being replaced as Iran’s top security official just two months after securing this diplomatic deal with Saudi Arabia, Shamkhani remained a key adviser to the Iranian Supreme Leader. In May, he said that Iran would be willing to sign a nuclear deal with Trump, subject to conditions that Iran could still enrich certain levels of uranium for energy use.

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“It’s still possible. If the Americans act as they say, for sure we can have better relations… It can lead to a better situation in the near future,” Shamkhani said, regarding possible talks with the U.S. during Trump’s three-country tour of the Middle East. Read more: Israel Gets the War It Wanted Nuclear Scientists On Saturday, the IDF reported it had “eliminated” nine senior scientists and experts responsible for advancing the Iranian regime’s nuclear weapons program. “Their elimination is a significant blow to the regime’s ability to acquire weapons of mass destruction,” a statement read. The scientists listed were: Fereydoun Abbasi, an expert in nuclear engineering and the former head of Iran’s atomic energy, who also served as an MP (Member of Parliament). Mohammad Mahdi, a physics expert. Akbar Motalebi Zadeh, a chemical engineering specialist. Saeed Barji, a materials engineering specialist. Ahmad Reza Zolfaghari Daryani, an expert in nuclear engineering. Ali Bakhouei Katirimi, an expert in mechanics. And three physics experts: Amir Hassan Fakhahi, Abd al-Hamid Minoushehr, and Mansour Asgari.

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Another scientist previously reported as killed by is Mohammad Mehdi Tehranchi, a theoretical physicist and a key expert involved in the AMAD plan, Iran’s significant programme to advance nuclear capabilities launched in the early 2000s. Tehranchi was also the President of Islamic Azad University in Tehran.

Seyed Amir Hossein Feqhi has also been reported as killed. Feqhi was deputy head of the Atomic Energy Organization of Iran, and served on the nuclear engineering faculty at Shahid Beheshti University in Tehran.

Israel-Iran Conflict Day 6 LIVE Updates: The deadly conflict between Iran and Israel entered its fifth day on Tuesday, with both sides widening their attacks. Israeli air strikes have killed at least 224 people in Iran, including some of Tehran’s top military commanders, nuclear scientists and civilians. The Israeli authorities have said that at least 24 people, including women and children, were killed in Iranian attacks on their territory. Israel’s army warned early on Tuesday that it had detected new missiles launched from Iran.

US President Donald Trump was on Monday leaving a Group of Seven summit early as he hinted at greater involvement in the Israel-Iran conflict and warned Tehran residents to evacuate. Before flying out of Canada in the middle of the G7 gathering, he took to social media to back Israel and issue an alert to the Iranian capital of nearly 10 million people.

The situation deteriorated in Middle East after Israel’s large-scale attacks on Friday aimed at crippling Iran’s nuclear and military infrastructure, sparking retaliation. The fierce exchanges of fire came amid talks between Tehran and Washington seeking to reach a deal on Iran’s nuclear programme.

Israeli Prime Minister Benjamin Netanyahu said he believes the Jewish state’s offensives have significantly set back Tehran’s nuclear program. “I estimate we are sending them back a very, very long time,” he said in a news conference.

Here Are The LIVE Updates On Israel-Iran Attacks:

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Intense Israeli airstrikes targeted Iran’s capital, Tehran, early on Wednesday after it issued a warning about a new area it could target.

A major explosion could be heard around 5 am local time in Tehran. Iranian officials offered no acknowledgement of the attacks, which has become increasingly common as the Israeli airstrike campaign has intensified since it began on Friday.

The Israelis earlier warned they could strike a neighbourhood south of Mehrabad International Airport, which includes residential buildings, military installations, pharmaceutical companies and industrial firms.

The attacks come just a day after US President Donald Trump warned Tehran’s residents to evacuate and demanded the country’s unconditional surrender.

Trump departed the Group of Seven summit – or G7 – in Canada a day ahead of schedule to address the ongoing conflict between Israel and Iran. He informed reporters, “I’m not looking at a ceasefire. We’re looking at better than a ceasefire.”

A man takes a cellphone photo as missiles fired from Iran toward Israel fly over Syrian territory in Damascus, Syria, early Wednesday, June 18, 2025 Ghaith Alsayed/Copyright 2025 The AP. All rights reserved.

When asked to explain, he said Washington is seeking “a real end” to the conflict that could involve Iran “giving up entirely.” He added: “I’m not too much in the mood to negotiate.”

He later issued a warning to Iran’s Supreme Leader Ayatollah Ali Khamenei that the US is aware of his whereabouts and his hiding spot and called for Iran’s “UNCONDITIONAL SURRENDER”.

It was not clear whether Trump was suggesting Tehran abandon its nuclear ambitions altogether or end the current wave of attacks.

Trump posted that there were no plans to kill Khamenei “at least not for now.” Despite warning that US’ “patience is wearing thin,” he indicated that diplomacy remains an option, adding that he could send Vice President JD Vance and special envoy Steve Witkoff to meet with the Iranians.

Iran offered no immediate response to the president’s posts, but the country’s military leaders vowed that Israel would soon see more attacks.

“The operations carried out so far have been solely for the purpose of warning and deterrence,” Gen. Abdul Rahim Mousavi, the commander in chief of Iran’s army, said in a video. “The punishment operation will be carried out soon.”

Iran’s newly appointed commander reportedly assassinated

Iran has not provided an immediate response regarding the reported assassination of General Ali Shadmani in the Iranian capital, who was described by Israel as the highest-ranking military commander.

Prior to his recent appointment last week to a chief-of-staff-like position as the head of Iran’s Revolutionary Guard Corps’ (IRGC) Khatam al-Anbiya Central Headquarters, Shadmani was relatively unknown within the country.

This appointment came in the wake of the assassination of his predecessor, Gholam Ali Rashid, during an Israeli airstrike.

Israel announced a new wave of strikes on Tuesday evening as explosions and anti-aircraft fire boomed throughout Tehran, shaking buildings. The Israeli military said its warplanes had targeted 12 missile launch sites and storage facilities.

Israel’s military warned the population to stay close to shelters as Iran fired a new barrage of missiles, but officials said most were intercepted.

Sirens sounded in southern Israel, including in the desert town of Dimona, the heart of Israel’s never-acknowledged nuclear arms programme. Iran launched another barrage early on Wednesday. Israeli rescue services reported no immediate deaths or injuries.

Scores of people flee Tehran

Early on Tuesday, downtown Tehran saw a significant decrease in activity, with numerous shops closed, including the historic Grand Bazaar, which typically shuts its doors only during periods of crisis, such as the 2022 anti-government protests and the coronavirus pandemic.

On the roads out of Tehran to the west, traffic stood bumper to bumper. Many middle- and upper-class Iranians were headed to the Caspian Sea, a popular getaway spot. Long lines snaked from Tehran’s gas stations.

Tehran is one of the largest cities in the Middle East, with around 10 million residents, roughly equivalent to Israel’s entire population.

Nuclear watchdog reports significant damage to Iranian facilities

The International Atomic Energy Agency (IAEA) stated its belief that Israel’s initial aerial assaults on Iran’s Natanz enrichment site had a direct impact on the facility’s underground centrifuge operations.

Satellite imagery collected after Friday’s attacks showed “additional elements that indicate direct impacts on the underground enrichment halls,” the watchdog said.

The IAEA earlier reported that Israeli strikes had destroyed an above-ground enrichment hall at Natanz and knocked out electrical equipment that powered the facility. Most of Iran’s enrichment takes place underground however to protect from airstrikes.

This satellite image provided by Maxar Technologies shows the Natanz nuclear enrichment facility, where multiple buildings were destroyed from recent Israeli airstrikes AP/Satellite image ©2025 Maxar Technologies

Israel has struck Natanz repeatedly and claims to have hurt its underground facilities, which experts assess contain 10,000 centrifuges that enrich uranium up to 60%.

Iran asserts that its nuclear programme is peaceful, while the United States and other nations have determined that Tehran has not engaged in a systematic effort to develop a nuclear weapon since 2003.

The IAEA has routinely warned that the nation possesses sufficient enriched uranium to manufacture multiple nuclear bombs if it so decides to pursue that path.

While Israeli Prime Minister Benjamin Netanyahu claims that strikes on Iran’s nuclear facilities have delayed the nation’s nuclear programme by a ” very, very long time”, Israel has yet to successfully target Iran’s Fordo facility, which lies deep within a mountainside.

Hitting Fordo would require the US to get involved militarily and deploy B-2 stealth bombers to drop its bunker-busting bomb. The 14,000 kg GBU-57 Massive Ordnance Penetrator uses its weight and sheer kinetic force to reach deeply buried targets.

A pro-Israel hacker group called Predatory Sparrow claimed a cyberattack on a major Iranian national bank today.

The group bragged on X and Telegram that it had deleted key files from Bank Sepah. Its membership is unknown, and it’s unclear whether it has any potential affiliation with Israeli military or intelligence services.

Iran’s National Cybersecurity Command claimed Israeli hackers were attacking its digital infrastructure to disrupt public services, though it didn’t specify what was affected.

A source on the ground told NBC News that some ATMs weren’t functional today. Bank Sepah didn’t respond to an email requesting comment.