The vehicle arrived in April with plenty of food, equipment and other supplies for the seven astronauts currently living aboard the station.

When it undocks, it will be loaded up with scientific research samples and hardware bound for Earth.

The spacecraft will splash down on Friday, May 23, off the coast of California.

A SpaceX vehicle that has spent about a month docked at the International Space Station on a resupply mission is due to depart within a matter of hours.

NASA will provide live coverage as the uncrewed spacecraft begins its return voyage Thursday, May 22. The Dragon capsule, developed by Elon Musk’s commercial spaceflight company to deliver cargo and crews to the orbital outpost, will then embark on a long voyage ending with a splashdown landing Friday, May 23, off the coast of California.

The vehicle arrived in April with plenty of food, equipment and other supplies for the seven astronauts currently living aboard the station. And it’s not leaving emptyhanded: When it undocks, it will be loaded up with scientific research samples and hardware bound for Earth.

Here’s what to know about the resupply mission and how to watch the U.S. space agency’s coverage of the Dragon’s departure:

What is the International Space Station?

For 25 years, the International Space Station has been stationed in low-Earth orbit, typically about 250 miles high, where it has been home to astronauts from all over the world.

The orbital laboratory is operated through a global partnership of space agencies, including NASA, Roscosmos, the European Space Agency, the Japan Aerospace Exploration Agency (JAXA) and the Canadian Space Agency (CSA).

More than 280 spacefarers from 23 countries have visited the International Space Station, including 169 from the United States alone, according to NASA. Bigger than a six-bedroom house, the outpost has six sleeping quarters, two bathrooms, a gym and a 360-degree view bay window.

As of now, seven members of Expedition 73, including three Americans, are living aboard the ISS – conducting scientific research and working to maintain the station.

SpaceX Dragon to depart from ISS

The crew members aboard the station spent time Wednesday, May 21, loading and securing a variety of cargo inside the Dragon spacecraft ahead of its scheduled departure.

The Dragon has spent 30 days docked to the Harmony module, a port and passageway onto the station facing away from Earth, after arriving April 22 with nearly 6,700 pounds of supplies. The spacecraft launched April 21 on a SpaceX Falcon 9 rocket from NASA’s Kennedy Space Center near Cape Canaveral, Florida, for SpaceX’s 32nd commercial resupply services mission.

Standing nearly 27 feet tall and about 13 feet wide, the Dragon is one of four cargo spacecraft that deliver science experiments and other cargo to the space station on a regular basis. Dragon capsules can also carry up to seven astronauts into orbit, though most of SpaceX’s Crew missions, which are contracted with NASA, feature a contingent of four.

The Dragon is due to undock at about 12:05 p.m. ET Thursday, May 22, from the Harmony module before firing its thrusters to move away from the station. The departure will be under command by SpaceX’s Mission Control in Hawthorne, California.

NASA to stream coverage of SpaceX vehicle undocking

NASA will provide live coverage of the undocking beginning at 11:45 a.m. ET Thursday on its streaming service, NASA+.

SpaceX capsule to land off California coast

After re-entering Earth’s atmosphere, the spacecraft will splash down on Friday, May 23, off the coast of California. While NASA will post updates on the agency’s space station blog, it will not provide a livestream of the water landing.

Eric Lagatta is the Space Connect reporter for the USA TODAY Network. Reach him at elagatta@gannett.com